Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits
نویسندگان
چکیده
منابع مشابه
Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.
Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations.
متن کاملTopical dexamethasone-cyclodextrin microparticle eye drops for diabetic macular edema.
PURPOSE To test the safety and efficacy of topical 1.5% dexamethasone aqueous eye drops with cyclodextrin microparticles for diabetic macular edema (DME). METHODS Nineteen eyes of 19 consecutive patients with DME were administered dexamethasone-cyclodextrin eye drops three or six times a day for 4 weeks and then observed for 4 weeks without treatment. Visual acuity, intraocular pressure, and ...
متن کاملPharmacokinetics and Efficacy of Topically Applied Nonsteroidal Anti-Inflammatory Drugs in Retinochoroidal Tissues in Rabbits
PURPOSE To evaluate the pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) in the retinochoroidal tissues of rabbits. METHODS The cyclooxygenase (COX) inhibitory activity of diclofenac, bromfenac, and amfenac, an active metabolite of nepafenac, were determined using human-derived COX-1 and COX-2. Each of the three NSAIDs was applied topically to r...
متن کاملEfficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection
PURPOSE We examined the efficacy of retinol palmitate (VApal) for dry eyes using dry eye model rabbits whose lacrimal glands were resected. MATERIALS AND METHODS After alkaline injury on keratoconjunctival epithelium, VApal eye drops were administered 6 times a day for 7 days. The efficacy of VApal was also compared with that of 0.1% hyaluronic acid eye drops. RESULTS The fluorescein staini...
متن کاملcoordination of protective schemes in distribution and subtransmission systems including distributed generation
نصب منابع پراکنده در سیستم های توزیع و فوق توزیع علاوه بر مزیت های فراوان، مشکلاتی را هم به همراه دارد. یکی از این مشکلات تأثیر این منابع روی اندازه جریان های اتصال کوتاه است. به طور معمول از حفاظت های مبتنی بر اصل جریان زیاد در سیستم های توزیع و فوق توزیع استفاده می شود. از مهمترین طرح های حفاظتی استفاده شده در فیدرهای توزیع، حفاظت فیوز- ریکلوزر است. همچنین از طرح های حفاظتی جریان زیاد جهتی در...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2021
ISSN: 1424-8247
DOI: 10.3390/ph14050480